SLC12A1

Across TCGA patient cohorts, SLC12A1 mutation is significantly associated with the RNA expression of many other genes, with 6,519 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC12A1-associated genes across cancer lineages are OIP5, CACYBP, and DUT. Each is linked with SLC12A1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC12A1-to-partner and partner-to-SLC12A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OIP5 grouped by SLC12A1-low versus SLC12A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A1→partner) and Y-score (partner→SLC12A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OIP5 →	+0.802	+2.191	<.001	<.001	3	5
STAD	CACYBP →	+0.702	+3.622	<.001	.001	3	5
SKCM	DUT →	+0.573	+3.604	.001	.001	3	5
SKCM	PARP2 →	+0.599	+3.870	<.001	<.001	3	5
UCEC	MRPL34 →	+0.247	+1.654	.006	.001	3	5
SKCM	EXO1 →	+0.605	+3.472	.008	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,519 associations by consensus.

OIP5 by SLC12A1 expression — UCEC

Explore this box plot interactively →