SLC12A1

Across TCGA patient cohorts, SLC12A1 mutation is significantly associated with the total protein of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC12A1-associated genes across cancer lineages are ATM, FoxM1, and RBM15. Each is linked with SLC12A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC12A1-to-partner and partner-to-SLC12A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SLC12A1-low versus SLC12A1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A1→partner) and Y-score (partner→SLC12A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ATM →	-0.698	-2.303	<.001	.031	3	3
STAD	FoxM1 →	+0.388	+3.169	<.001	.017	3	3
STAD	RBM15 →	+0.558	+3.321	.003	.009	3	3
UCEC	Cyclin-B1 →	+0.588	+2.736	<.001	<.001	3	3
STAD	53BP1 →	+0.520	+3.169	.002	.017	3	3
STAD	Dvl3 →	+0.184	+2.185	.011	.032	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

ATM by SLC12A1 expression — LUSC

Explore this box plot interactively →