SLC12A1

Across TCGA cell cohorts, SLC12A1 mutation is significantly associated with the RNA expression of many other genes, with 512 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC12A1-associated genes across cancer lineages are TMEM178B, C10orf53, and OPN4. Each is linked with SLC12A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC12A1-to-partner and partner-to-SLC12A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM178B grouped by SLC12A1-low versus SLC12A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A1→partner) and Y-score (partner→SLC12A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM178B →	+0.878	+2.517	<.001	.006	3	2
OESOPHAGUS	C10orf53 →	+0.023	+4.906	<.001	.006	3	1
PANCREAS	OPN4 →	+0.045	+3.652	<.001	.001	3	1
PANCREAS	OR4X2 →	+0.021	+3.554	<.001	.003	3	1
PANCREAS	MRGPRD →	+0.038	+4.022	.005	.001	3	1
PANCREAS	ZNF479 →	+0.014	+4.554	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 512 associations by consensus.

TMEM178B by SLC12A1 expression — LARGE_INTESTINE

Explore this box plot interactively →