SLC11A2

Across TCGA patient cohorts, SLC11A2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC11A2-associated genes across cancer lineages are p38-MAPK_pT180_Y182, EGFR_pY1068, and eIF4E. Each is linked with SLC11A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC11A2-to-partner and partner-to-SLC11A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by SLC11A2-low versus SLC11A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC11A2→partner) and Y-score (partner→SLC11A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.337	-2.321	.017	.033	3	2
UCEC	EGFR_pY1068 →	-0.159	-1.137	.044	.041	3	1
UCEC	eIF4E →	+0.156	+2.598	.018	.005	3	1
UCEC	A-Raf_pS299 →	-0.076	-1.906	.042	.015	3	1
UCEC	FASN →	+0.358	+1.584	.003	.017	3	1
UCEC	FoxM1 →	+0.234	+1.836	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

p38-MAPK_pT180_Y182 by SLC11A2 expression — UCEC

Explore this box plot interactively →