SLC11A1

Across TCGA patient cohorts, SLC11A1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC11A1-associated genes across cancer lineages are MEK1, ASNS, and ATM. Each is linked with SLC11A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC11A1-to-partner and partner-to-SLC11A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SLC11A1-low versus SLC11A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC11A1→partner) and Y-score (partner→SLC11A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.343	+1.678	.014	.023	3	2
UCEC	ASNS →	+0.317	+1.807	.022	.025	3	2
UCEC	ATM →	-0.493	-3.459	.004	.005	3	2
UCEC	eEF2 →	+0.430	+2.807	.001	.003	3	1
UCEC	EGFR_pY1068 →	-0.219	-2.115	.022	.017	3	1
UCEC	ERK2 →	+0.246	+2.087	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MEK1 by SLC11A1 expression — UCEC

Explore this box plot interactively →