SLC11A1

Across TCGA cell cohorts, SLC11A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,454 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC11A1-associated GO terms across cancer lineages are Regulation of endocrine process, Negative regulation of ubiquitin-dependent protein catabolic process, and AV node cell to bundle of His cell communication by electrical coupling. Each is linked with SLC11A1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SLC11A1-to-partner and partner-to-SLC11A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of endocrine process grouped by SLC11A1-low versus SLC11A1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC11A1→partner) and Y-score (partner→SLC11A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of endocrine process →	-0.068	-0.242	.006	<.001	3	7
BLOOD_Leukemia	Negative regulation of ubiquitin-dependent protein catabolic process →	+0.030	+0.384	.001	.001	3	7
LARGE_INTESTINE	AV node cell to bundle of His cell communication by electrical coupling →	-0.809	-0.284	.002	<.001	3	6
PANCREAS	Regulation of myoblast fusion →	+0.081	+0.217	.001	.003	3	6
KIDNEY	Negative regulation of myoblast fusion →	+0.081	+0.131	<.001	.008	3	6
PANCREAS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.056	+0.164	.005	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,454 associations by consensus.

Regulation of endocrine process by SLC11A1 expression — LARGE_INTESTINE

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