SLC10A4

Across TCGA patient cohorts, SLC10A4 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC10A4-associated genes across cancer lineages are PDCD4, 14-3-3_beta, and A-Raf_pS299. Each is linked with SLC10A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC10A4-to-partner and partner-to-SLC10A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SLC10A4-low versus SLC10A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC10A4→partner) and Y-score (partner→SLC10A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.747	-2.990	<.001	.036	3	2
UCEC	14-3-3_beta →	-0.118	-2.973	.015	.035	3	1
UCEC	A-Raf_pS299 →	-0.176	-2.999	.002	.035	3	1
UCEC	Ku80 →	+0.259	+2.472	.023	.011	3	1
UCEC	PCNA →	+0.381	+3.584	<.001	.002	3	1
UCEC	STAT3_pY705 →	-0.353	-2.999	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

PDCD4 by SLC10A4 expression — UCEC

Explore this box plot interactively →