SLAMF7

Across TCGA patient cohorts, SLAMF7 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLAMF7-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and ERK2. Each is linked with SLAMF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLAMF7-to-partner and partner-to-SLAMF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SLAMF7-low versus SLAMF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLAMF7→partner) and Y-score (partner→SLAMF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.185	+3.321	.038	.010	3	1
UCEC	A-Raf_pS299 →	-0.157	-2.584	.001	.010	3	1
UCEC	ERK2 →	+0.174	+1.700	.033	.044	3	1
UCEC	FoxM1 →	+0.246	+1.700	.025	.044	3	1
UCEC	JNK2 →	+0.191	+1.700	.023	.044	3	1
UCEC	mTOR_pS2448 →	-0.159	-3.439	.011	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eIF4E by SLAMF7 expression — UCEC

Explore this box plot interactively →