SLAMF7

Across TCGA cell cohorts, SLAMF7 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,003 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SLAMF7-associated GO terms across cancer lineages are Regulation of proteolysis, Membrane assembly, and Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Each is linked with SLAMF7 in more than 9 cancer types. Because this analysis shows association rather than direction, both SLAMF7-to-partner and partner-to-SLAMF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of proteolysis grouped by SLAMF7-low versus SLAMF7-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLAMF7→partner) and Y-score (partner→SLAMF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of proteolysis →	+0.076	+2.043	<.001	<.001	3	10
OESOPHAGUS	Membrane assembly →	+0.096	+0.348	<.001	.008	3	9
BLOOD_Leukemia	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress →	+0.096	+1.506	<.001	.001	3	9
LUNG_NSCLC_LUAD	Cell-substrate junction organization →	+0.172	+1.569	<.001	<.001	3	8
SKIN	Regulation of tolerance induction dependent upon immune response →	+0.821	+2.158	<.001	<.001	3	8
BREAST	Positive regulation of intracellular transport →	+0.059	+0.879	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,003 associations by consensus.

Regulation of proteolysis by SLAMF7 expression — URINARY_TRACT

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