SLAMF7

Across TCGA cell cohorts, SLAMF7 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SLAMF7-associated genes across cancer lineages are PPDPFL, OR10W1, and OR10Q1. Each is linked with SLAMF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLAMF7-to-partner and partner-to-SLAMF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPDPFL grouped by SLAMF7-low versus SLAMF7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLAMF7→partner) and Y-score (partner→SLAMF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPDPFL →	+0.048	+4.217	<.001	.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.019	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	OR10Q1 →	+0.105	+3.920	.002	.005	3	1
SKIN	SLC10A2 →	+0.003	+4.022	<.001	.006	3	1
SKIN	KCNH6 →	+0.029	+3.874	<.001	.005	3	1
SKIN	OR52A1 →	+0.043	+3.196	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PPDPFL by SLAMF7 expression — LARGE_INTESTINE

Explore this box plot interactively →