SLAMF6

Across TCGA patient cohorts, SLAMF6 mutation is significantly associated with the RNA expression of many other genes, with 2,594 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLAMF6-associated genes across cancer lineages are GLRX5, SIVA1, and IFRD2. Each is linked with SLAMF6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLAMF6-to-partner and partner-to-SLAMF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLRX5 grouped by SLAMF6-low versus SLAMF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLAMF6→partner) and Y-score (partner→SLAMF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GLRX5 →	+0.470	+2.354	.001	.003	3	3
UCEC	SIVA1 →	+0.502	+2.364	.003	.003	3	3
UCEC	IFRD2 →	+0.622	+2.617	<.001	.005	3	3
SKCM	PDSS1 →	+0.454	+2.106	.005	.003	3	3
LUSC	TRIM65 →	+0.473	+3.632	.002	.001	3	3
LUSC	LINC02585 →	+0.614	+3.486	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,594 associations by consensus.

GLRX5 by SLAMF6 expression — UCEC

Explore this box plot interactively →