SLAMF1

Across TCGA patient cohorts, SLAMF1 mutation is significantly associated with the RNA expression of many other genes, with 3,580 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLAMF1-associated genes across cancer lineages are FRRS1, ITGAE, and RPL23AP53. Each is linked with SLAMF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLAMF1-to-partner and partner-to-SLAMF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FRRS1 grouped by SLAMF1-low versus SLAMF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLAMF1→partner) and Y-score (partner→SLAMF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FRRS1 →	+0.546	+2.321	.005	.006	3	3
UCEC	ITGAE →	+0.613	+3.643	<.001	<.001	3	3
UCEC	RPL23AP53 →	+0.501	+2.609	<.001	<.001	3	3
UCEC	RPL23AP7 →	+0.524	+2.523	<.001	<.001	3	3
UCEC	RPF1 →	+0.396	+1.896	.007	.004	3	3
UCEC	TMEM269 →	+0.169	+1.839	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,580 associations by consensus.

FRRS1 by SLAMF1 expression — UCEC

Explore this box plot interactively →