SLAMF1

Across TCGA patient cohorts, SLAMF1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLAMF1-associated genes across cancer lineages are Notch1, MEK1, and eIF4E. Each is linked with SLAMF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLAMF1-to-partner and partner-to-SLAMF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SLAMF1-low versus SLAMF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLAMF1→partner) and Y-score (partner→SLAMF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Notch1 →	+0.257	+2.815	.011	.036	3	3
UCEC	MEK1 →	+0.522	+4.000	<.001	<.001	3	3
UCEC	eIF4E →	+0.218	+2.087	.007	.005	3	2
UCEC	FoxM1 →	+0.211	+1.678	.033	.023	3	2
UCEC	GATA6 →	-0.139	-2.495	.021	.002	3	2
UCEC	Heregulin →	-0.132	-2.308	.005	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Notch1 by SLAMF1 expression — COAD

Explore this box plot interactively →