SLAIN2

Across TCGA patient cohorts, SLAIN2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLAIN2-associated genes across cancer lineages are p62 Lck ligand, MEK1, and Rad50. Each is linked with SLAIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLAIN2-to-partner and partner-to-SLAIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by SLAIN2-low versus SLAIN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLAIN2→partner) and Y-score (partner→SLAIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.331	+2.817	.035	.036	3	2
UCEC	MEK1 →	+0.413	+3.000	.019	.036	3	1
UCEC	Rad50 →	-0.292	-2.459	.012	.020	2	2
UCEC	STAT3_pY705 →	-0.343	-2.459	.006	.020	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.538	+2.459	.028	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p62 Lck ligand by SLAIN2 expression — UCEC

Explore this box plot interactively →