SLA2

Across TCGA patient cohorts, SLA2 mutation is significantly associated with the RNA expression of many other genes, with 211 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLA2-associated genes across cancer lineages are H3C15, MIR586, and RPS29P31. Each is linked with SLA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLA2-to-partner and partner-to-SLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H3C15 grouped by SLA2-low versus SLA2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLA2→partner) and Y-score (partner→SLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	H3C15 →	+0.033	+4.392	<.001	.006	3	2
LUSC	MIR586 →	+0.339	+5.733	<.001	.001	3	2
LUSC	RPS29P31 →	+0.412	+4.447	<.001	.006	3	2
LUSC	SAR1AP3 →	+0.142	+4.187	<.001	.009	3	2
LUSC	NIPA2P5 →	+0.139	+4.625	<.001	.008	3	2
BLCA	RNU6-794P →	+0.346	+5.814	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 211 associations by consensus.

H3C15 by SLA2 expression — LUSC

Explore this box plot interactively →