SLA2

Across TCGA patient cohorts, SLA2 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLA2-associated genes across cancer lineages are NF2, TIGAR, and HER2. Each is linked with SLA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLA2-to-partner and partner-to-SLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by SLA2-low versus SLA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLA2→partner) and Y-score (partner→SLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF2 →	+0.315	+3.000	.011	.037	3	1
UCEC	TIGAR →	+0.190	+3.026	.031	.019	3	1
UCEC	HER2 →	+0.583	+3.000	.026	.037	1	1
UCEC	Annexin-1 →	+0.850	+3.000	.005	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

NF2 by SLA2 expression — UCEC

Explore this box plot interactively →