SLA

Across TCGA patient cohorts, SLA protein abundance is significantly associated with the RNA expression of many other genes, with 1,079 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SLA-associated genes across cancer lineages are CTNND1, ARHGEF9-IT1, and MAPK1. Each is linked with SLA in more than 1 cancer types. Because this analysis shows association rather than direction, both SLA-to-partner and partner-to-SLA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SLA versus CTNND1 in LSCC, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLA→partner) and Y-score (partner→SLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CTNND1 →	-0.397	-0.339	.006	.007	3	2
LSCC	ARHGEF9-IT1 →	-0.450	-0.376	.004	.001	3	2
LSCC	MAPK1 →	-0.344	-0.286	.004	.001	3	1
LSCC	CRYBB3 →	-0.697	-0.335	.006	.004	3	1
LSCC	ESS2 →	-0.321	-0.250	.005	.005	3	1
LSCC	HPS4 →	-0.536	-0.492	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,079 associations by consensus.

SLA vs CTNND1 — LSCC

Explore this scatter interactively →