SLA

Across TCGA patient cohorts, SLA mutation is significantly associated with the RNA expression of many other genes, with 3,111 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLA-associated genes across cancer lineages are MIR670, RNA5SP136, and BTBD6. Each is linked with SLA in more than 2 cancer types. Because this analysis shows association rather than direction, both SLA-to-partner and partner-to-SLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR670 grouped by SLA-low versus SLA-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLA→partner) and Y-score (partner→SLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR670 →	+0.445	+4.730	<.001	.005	3	3
THCA	RNA5SP136 →	+0.353	+7.962	<.001	.007	3	2
UCEC	BTBD6 →	+0.310	+2.828	.003	.001	3	2
UCEC	ERCC6L →	+0.621	+2.818	<.001	.001	3	2
UCEC	PRIM1 →	+0.654	+2.410	<.001	<.001	3	2
UCEC	POLH-AS1 →	+0.503	+2.378	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,111 associations by consensus.

MIR670 by SLA expression — LUAD

Explore this box plot interactively →