SLA

Across TCGA patient cohorts, SLA mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLA-associated genes across cancer lineages are JNK_pT183_Y185, TFRC, and Bax. Each is linked with SLA in more than 1 cancer types. Because this analysis shows association rather than direction, both SLA-to-partner and partner-to-SLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SLA-low versus SLA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLA→partner) and Y-score (partner→SLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.200	-2.321	<.001	.005	3	2
UCEC	TFRC →	+0.500	+2.070	.006	.001	3	2
UCEC	Bax →	+0.175	+1.700	.035	.040	3	2
UCEC	Caspase-8 →	-0.255	-3.143	.003	<.001	3	2
UCEC	C-Raf →	+0.142	+1.678	.004	.021	3	2
UCEC	eEF2 →	+0.438	+2.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

JNK_pT183_Y185 by SLA expression — UCEC

Explore this box plot interactively →