SLA

Across TCGA cell cohorts, SLA mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLA-associated genes across cancer lineages are OR11H1, SLCO1C1, and CER1. Each is linked with SLA in more than 1 cancer types. Because this analysis shows association rather than direction, both SLA-to-partner and partner-to-SLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H1 grouped by SLA-low versus SLA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLA→partner) and Y-score (partner→SLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR11H1 →	+0.080	+5.786	<.001	<.001	3	1
BLOOD_Leukemia	SLCO1C1 →	+0.096	+4.705	<.001	.003	3	1
BLOOD_Leukemia	CER1 →	+1.039	+4.152	<.001	.009	3	1
BLOOD_Leukemia	LYZL4 →	+0.088	+4.152	<.001	.009	3	1
BLOOD_Leukemia	OR4K2 →	+0.031	+4.969	<.001	.003	3	1
BLOOD_Leukemia	IL25 →	+0.062	+4.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

OR11H1 by SLA expression — BLOOD_Leukemia

Explore this box plot interactively →