SKP2

Across TCGA pan-cancer cohorts, SKP2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SKP2 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SKP2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SKP2 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC and PDAC are the cancer types where SKP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.892	0.595	.006	2	view →
PDAC	DFS	Median	All	0.831	1.000	.022	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SKP2–LSCC (OS)

Open the LSCC breakdown →