SKP2

Across TCGA patient cohorts, SKP2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SKP2-associated genes across cancer lineages are EGFR, PCNA, and Rab25. Each is linked with SKP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SKP2-to-partner and partner-to-SKP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by SKP2-low versus SKP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKP2→partner) and Y-score (partner→SKP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.261	-3.143	<.001	.018	3	1
UCEC	PCNA →	+0.201	+2.000	.039	.032	3	1
UCEC	Rab25 →	-0.362	-2.000	.015	.032	3	1
UCEC	STAT3_pY705 →	-0.399	-2.000	<.001	.032	3	1
UCEC	Tuberin_pT1462 →	+0.310	+2.469	.002	.010	3	1
UCEC	VHL →	-1.022	-2.000	<.001	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR by SKP2 expression — UCEC

Explore this box plot interactively →