SKP2

Across TCGA cell cohorts, SKP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,926 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SKP2-associated GO terms across cancer lineages are Protein localization to nuclear inner membrane, DNA strand elongation involved in DNA replication, and DNA replication checkpoint signaling. Each is linked with SKP2 in more than 18 cancer types. Because this analysis shows association rather than direction, both SKP2-to-partner and partner-to-SKP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to nuclear inner membrane grouped by SKP2-low versus SKP2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SKP2→partner) and Y-score (partner→SKP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein localization to nuclear inner membrane →	+0.207	+1.822	<.001	<.001	3	19
SOFT_TISSUE	DNA strand elongation involved in DNA replication →	+0.173	+1.978	<.001	<.001	3	19
OESOPHAGUS	DNA replication checkpoint signaling →	+0.176	+1.430	.002	.002	3	19
SOFT_TISSUE	Mitotic cell cycle phase transition →	+0.083	+1.984	<.001	<.001	3	18
BONE	Mitotic DNA integrity checkpoint signaling →	+0.105	+1.626	.005	.001	3	18
BONE	Nuclear pore organization →	+0.148	+1.236	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,926 associations by consensus.

Protein localization to nuclear inner membrane by SKP2 expression — BONE

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