SKP2

Across TCGA cell cohorts, SKP2 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SKP2-associated genes across cancer lineages are CBY1, USP14, and CLUAP1. Each is linked with SKP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SKP2-to-partner and partner-to-SKP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by SKP2-low versus SKP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKP2→partner) and Y-score (partner→SKP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.683	+3.160	.001	.006	3	1
LARGE_INTESTINE	USP14 →	+0.830	+3.087	<.001	.006	3	1
LARGE_INTESTINE	CLUAP1 →	+0.646	+3.215	.006	.009	3	1
LARGE_INTESTINE	PCCB →	+0.640	+3.125	.001	.008	3	1
LARGE_INTESTINE	ALDH6A1 →	+1.257	+3.064	<.001	.009	3	1
LARGE_INTESTINE	ADCY10 →	+0.129	+3.302	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

CBY1 by SKP2 expression — LARGE_INTESTINE

Explore this box plot interactively →