SKP1

Across TCGA pan-cancer cohorts, SKP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SKP1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SKP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SKP1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

LSCC, CCRCC, and GBM are the cancer types where SKP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.749	0.930	.007	12	view →
CCRCC	DFS	Median	III,IV	0.928	0.128	.014	6	view →
GBM	OS	Quartile	All	0.307	0.756	.011	4	view →
PDAC	DFS	Tertile	All	0.503	0.331	.014	4	view →
LUAD	OS	Quartile	III,IV	0.815	0.285	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SKP1–LSCC (OS)

Open the LSCC breakdown →