SKP1

Across TCGA patient cohorts, SKP1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,604 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SKP1-associated genes across cancer lineages are FBXO2, SCCPDH, and LYRM1. Each is linked with SKP1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SKP1-to-partner and partner-to-SKP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SKP1 versus FBXO2 in OV, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKP1→partner) and Y-score (partner→SKP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FBXO2 →	+1.947	+0.413	<.001	<.001	3	7
BRCA	SCCPDH →	+0.844	+0.195	<.001	<.001	3	6
BRCA	LYRM1 →	+0.788	+0.299	<.001	<.001	3	5
UCEC	TMEM205 →	+0.986	+0.129	<.001	<.001	3	4
OV	EPAS1 →	-1.165	-0.453	<.001	<.001	3	4
COAD	NID1 →	-1.096	-0.201	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,604 associations by consensus.

SKP1 vs FBXO2 — OV

Explore this scatter interactively →