SKP1

Across TCGA cell cohorts, SKP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,753 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SKP1-associated GO terms across cancer lineages are Positive regulation of t-circle formation, 7-methylguanosine mRNA capping, and Endoplasmic reticulum to Golgi vesicle-mediated transport. Each is linked with SKP1 in more than 12 cancer types. Because this analysis shows association rather than direction, both SKP1-to-partner and partner-to-SKP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of t-circle formation grouped by SKP1-low versus SKP1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SKP1→partner) and Y-score (partner→SKP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of t-circle formation →	-0.204	-1.030	<.001	<.001	3	13
OESOPHAGUS	7-methylguanosine mRNA capping →	+0.092	+0.704	.002	.008	2	11
CNS	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.063	+0.499	<.001	<.001	3	10
CNS	Vesicle budding from membrane →	+0.056	+0.495	<.001	<.001	3	10
BREAST	Vesicle coating →	+0.083	+0.753	<.001	<.001	3	10
OESOPHAGUS	7-methylguanosine RNA capping →	+0.092	+0.704	.002	.008	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,753 associations by consensus.

Positive regulation of t-circle formation by SKP1 expression — STOMACH

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