SKINT1L

Across TCGA pan-cancer cohorts, SKINT1L RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SKINT1L data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SKINT1L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SKINT1L expression acts as an unfavorable survival marker, although some lineages such as BLCA and READ show a favorable association.

KIRC, BLCA, and LGG are the cancer types where SKINT1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.408	0.625	<.001	79	view →
BLCA	OS	Quartile	All	0.524	0.328	<.001	60	view →
LGG	DFS	Median	All	0.311	0.482	<.001	54	view →
LUSC	DFS	Quartile	III,IV	0.523	0.826	.004	42	view →
READ	OS	Median	III,IV	0.975	0.806	.011	19	view →
BRCA	OS	Tertile	II,III,IV	0.946	0.876	.001	15	view →
SKCM	OS	Quartile	IV	0.993	0.436	.001	15	view →
LIHC	DFS	Quartile	All	0.281	0.478	.009	14	view →
KIRP	DFS	Tertile	III,IV	0.620	0.960	.009	13	view →
LUAD	DFS	Tertile	III,IV	0.512	0.198	.020	11	view →
OV	OS	Quartile	IV	0.497	0.842	.020	10	view →
PRAD	DFS	Quartile	All	0.805	0.916	.008	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SKINT1L–KIRC (DFS)

Open the KIRC breakdown →