SKI

Across TCGA patient cohorts, SKI mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SKI-associated genes across cancer lineages are PCNA, Src_pY527, and EGFR_pY1068. Each is linked with SKI in more than 1 cancer types. Because this analysis shows association rather than direction, both SKI-to-partner and partner-to-SKI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SKI-low versus SKI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKI→partner) and Y-score (partner→SKI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.294	+2.321	<.001	.033	3	2
UCEC	Src_pY527 →	-0.380	-3.169	.028	.018	3	2
UCEC	EGFR_pY1068 →	-0.355	-3.459	<.001	.005	3	1
UCEC	A-Raf_pS299 →	-0.174	-3.459	<.001	.005	3	1
UCEC	FoxM1 →	+0.335	+2.710	.001	.003	3	1
UCEC	GATA6 →	-0.160	-2.307	.012	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

PCNA by SKI expression — UCEC

Explore this box plot interactively →