SKI

Across TCGA cell cohorts, SKI mutation is significantly associated with the RNA expression of many other genes, with 510 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SKI-associated genes across cancer lineages are KLHL40, CST9, and PSAPL1. Each is linked with SKI in more than 1 cancer types. Because this analysis shows association rather than direction, both SKI-to-partner and partner-to-SKI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by SKI-low versus SKI-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKI→partner) and Y-score (partner→SKI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	2
BLOOD_Lymphoma	CST9 →	+0.060	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	PSAPL1 →	+0.199	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	CYLC1 →	+0.029	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	C18orf63 →	+0.012	+4.867	<.001	.009	3	1
BLOOD_Leukemia	ODF1 →	+0.056	+4.266	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 510 associations by consensus.

KLHL40 by SKI expression — BLOOD_Lymphoma

Explore this box plot interactively →