SKAP2

Across TCGA pan-cancer cohorts, SKAP2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SKAP2 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SKAP2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SKAP2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, HNSC, and UCEC are the cancer types where SKAP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.866	1.000	.012	42	view →
HNSC	DFS	Tertile	III,IV	0.467	0.763	.025	10	view →
UCEC	OS	Median	II,III,IV	1.000	0.628	.013	8	view →
PDAC	DFS	Quartile	II,III,IV	0.594	0.922	.005	5	view →
LUAD	OS	Tertile	III,IV	0.176	0.748	.013	4	view →
LSCC	DFS	Median	II,III,IV	0.535	0.857	.008	4	view →
GBM	OS	Quartile	All	0.200	0.532	.007	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SKAP2–COAD (DFS)

Open the COAD breakdown →