SKAP2

Across TCGA patient cohorts, SKAP2 mutation is significantly associated with the RNA expression of many other genes, with 669 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SKAP2-associated genes across cancer lineages are MIR190B, ATP6V1G1P3, and RNU2-13P. Each is linked with SKAP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SKAP2-to-partner and partner-to-SKAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR190B grouped by SKAP2-low versus SKAP2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKAP2→partner) and Y-score (partner→SKAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR190B →	+0.260	+5.087	.002	.004	3	3
LUAD	ATP6V1G1P3 →	+0.250	+4.268	<.001	.008	3	3
LUSC	RNU2-13P →	+0.269	+4.496	<.001	.007	3	2
LUSC	MIR4484 →	+0.559	+4.307	.001	.003	3	2
SKCM	RNA5SP76 →	+0.208	+4.186	<.001	.007	3	2
UCEC	PRIM1 →	+0.762	+2.617	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 669 associations by consensus.

MIR190B by SKAP2 expression — LUAD

Explore this box plot interactively →