SKAP2

Across TCGA patient cohorts, SKAP2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SKAP2-associated genes across cancer lineages are MEK1, Myosin-IIa_pS1943, and p62 Lck ligand. Each is linked with SKAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SKAP2-to-partner and partner-to-SKAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SKAP2-low versus SKAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKAP2→partner) and Y-score (partner→SKAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.366	+3.169	.031	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.191	+2.598	.047	.006	3	1
UCEC	p62 Lck ligand →	+0.510	+3.179	<.001	.010	2	2
UCEC	Annexin-1 →	+0.569	+2.827	.020	.035	3	1
UCEC	STAT3_pY705 →	-0.383	-2.449	.001	.019	3	1
UCEC	VHL →	-1.038	-3.169	.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MEK1 by SKAP2 expression — UCEC

Explore this box plot interactively →