SKA2

Across TCGA patient cohorts, SKA2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SKA2-associated genes across cancer lineages are ERK2, NF-kB-p65_pS536, and PCNA. Each is linked with SKA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SKA2-to-partner and partner-to-SKA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SKA2-low versus SKA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKA2→partner) and Y-score (partner→SKA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.228	+2.000	.005	.030	3	1
UCEC	NF-kB-p65_pS536 →	-0.485	-3.169	.012	.018	3	1
UCEC	PCNA →	+0.223	+2.321	.014	.034	3	1
UCEC	Caspase-7-cleavedD198 →	+0.722	+3.341	.004	.005	3	1
UCEC	Cyclin-B1 →	+0.535	+3.169	.024	.018	3	1
UCEC	4E-BP1 →	+0.285	+2.837	.013	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ERK2 by SKA2 expression — UCEC

Explore this box plot interactively →