SIX5

Across TCGA pan-cancer cohorts, SIX5 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SIX5 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher SIX5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SIX5 expression acts as an unfavorable survival marker.

THCA, LIHC, and GBM are the cancer types where SIX5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Median	All	0.043	0.950	<.001	36	view →
LIHC	DFS	Median	All	0.096	0.546	<.001	18	view →
GBM	OS	Median	All	0.024	0.416	<.001	6	view →
COAD	OS	Median	All	0.506	0.804	.028	3	view →
LUAD	OS	Median	All	0.241	0.684	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SIX5–THCA (OS)

Open the THCA breakdown →