SIX5

Across TCGA pan-cancer cohorts, SIX5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SIX5 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SIX5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SIX5 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where SIX5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	1.000	0.849	.008	4	view →
HNSC	DFS	Tertile	III,IV	0.790	0.317	.049	2	view →
LUAD	OS	Tertile	III,IV	0.925	0.468	.035	2	view →
CCRCC	DFS	Median	All	1.000	0.698	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SIX5–PDAC (OS)

Open the PDAC breakdown →