SIX5

Across TCGA patient cohorts, SIX5 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,791 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIX5-associated proteins across cancer lineages are PTK7, PRR36, and ARHGAP35. Each is linked with SIX5 in more than 3 cancer types. Because this analysis shows association rather than direction, both SIX5-to-partner and partner-to-SIX5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIX5 versus PTK7 in COAD, with a Pearson correlation of 0.27.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX5→partner) and Y-score (partner→SIX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PTK7 →	+0.347	+0.456	.009	.001	3	4
LSCC	PRR36 →	+1.069	+0.357	.001	.001	3	3
LUAD	ARHGAP35 →	+0.235	+0.228	<.001	<.001	3	3
BRCA	STC2 →	+1.129	+0.687	<.001	.001	3	3
LUAD	UFM1 →	-0.214	-0.212	.001	.001	3	2
LSCC	RASAL3_S819 →	-0.681	-0.373	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,791 associations by consensus.

SIX5 vs PTK7 — COAD

Explore this scatter interactively →