SIX5

Across TCGA patient cohorts, SIX5 mutation is significantly associated with the RNA expression of many other genes, with 606 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIX5-associated genes across cancer lineages are RNU6-1156P, RNU6-552P, and MIR5583-1. Each is linked with SIX5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIX5-to-partner and partner-to-SIX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1156P grouped by SIX5-low versus SIX5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX5→partner) and Y-score (partner→SIX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-1156P →	+0.495	+4.396	<.001	.002	3	3
BLCA	RNU6-552P →	+0.363	+4.691	<.001	.001	3	2
COAD	MIR5583-1 →	+0.334	+4.917	.005	.003	3	2
COAD	RN7SL478P →	+0.289	+5.145	.001	<.001	3	2
CESC	GAGE12H →	+0.266	+4.837	<.001	.003	3	2
BLCA	MIR4479 →	+0.810	+4.506	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 606 associations by consensus.

RNU6-1156P by SIX5 expression — BLCA

Explore this box plot interactively →