SIX5

Across TCGA patient cohorts, SIX5 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIX5-associated genes across cancer lineages are EGFR_pY1068, ATM, and c-Kit. Each is linked with SIX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIX5-to-partner and partner-to-SIX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SIX5-low versus SIX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX5→partner) and Y-score (partner→SIX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.247	-2.584	.020	.010	3	2
UCEC	ATM →	-0.686	-1.700	<.001	.044	3	2
UCEC	c-Kit →	-0.254	-3.156	.010	.018	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.544	+2.009	.011	.017	3	1
UCEC	MSH6 →	-0.434	-2.459	.001	.018	3	1
UCEC	S6_pS240_S244 →	+0.411	+2.584	.017	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by SIX5 expression — UCEC

Explore this box plot interactively →