SIX5

Across TCGA cell cohorts, SIX5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,762 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SIX5-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Regulation of cytoplasmic pattern recognition receptor signaling pathway, and Negative regulation of transcription initiation by RNA polymerase II. Each is linked with SIX5 in more than 13 cancer types. Because this analysis shows association rather than direction, both SIX5-to-partner and partner-to-SIX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by SIX5-low versus SIX5-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX5→partner) and Y-score (partner→SIX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.169	+1.186	<.001	<.001	3	14
STOMACH	Regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.062	+0.878	<.001	<.001	3	14
LARGE_INTESTINE	Negative regulation of transcription initiation by RNA polymerase II →	+0.133	+1.041	<.001	<.001	3	13
BONE	Regulation of pattern recognition receptor signaling pathway →	+0.067	+1.384	.002	<.001	3	13
OESOPHAGUS	Cytosolic transport →	+0.096	+1.418	<.001	<.001	3	13
BONE	Negative regulation of calcium ion export across plasma membrane →	+0.079	+1.343	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,762 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by SIX5 expression — UPPER_AERODIGESTIVE_TRACT

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