SIX5

Across TCGA cell cohorts, SIX5 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIX5-associated genes across cancer lineages are MAGEB4, CCL19, and OR10G7. Each is linked with SIX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIX5-to-partner and partner-to-SIX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by SIX5-low versus SIX5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX5→partner) and Y-score (partner→SIX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MAGEB4 →	+0.006	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	CCL19 →	+0.135	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR10G7 →	+0.016	+5.662	<.001	.002	3	1
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	XAGE3 →	+0.107	+4.450	<.001	.001	3	1
BLOOD_Leukemia	TAS2R39 →	+0.062	+4.339	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

MAGEB4 by SIX5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →