SIX4

Across TCGA pan-cancer cohorts, SIX4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SIX4 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SIX4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SIX4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where SIX4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.756	0.918	.001	63	view →
UCEC	DFS	Tertile	II,III,IV	1.000	0.504	.008	22	view →
PDAC	DFS	Median	All	0.075	1.000	.038	12	view →
LSCC	OS	Median	All	1.000	0.767	.019	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SIX4–HNSC (OS)

Open the HNSC breakdown →