SIX2

Across TCGA patient cohorts, SIX2 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,676 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SIX2-associated proteins across cancer lineages are ZMYND8, ZFHX3_S3432, and MBP_S96. Each is linked with SIX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SIX2-to-partner and partner-to-SIX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIX2 versus ZMYND8 in LSCC, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX2→partner) and Y-score (partner→SIX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZMYND8 →	+0.334	+1.178	<.001	<.001	3	4
LUAD	ZFHX3_S3432 →	+0.496	+0.847	<.001	<.001	3	3
LUAD	MBP_S96 →	-0.487	-0.664	.001	<.001	3	3
LUAD	ZNF638_S1401 →	+0.464	+1.305	.002	<.001	3	3
HNSC	TNKS1BP1_S1666 →	-0.531	-0.723	<.001	<.001	3	3
HNSC	TOP2B_T1403 →	+0.611	+1.026	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,676 associations by consensus.

SIX2 vs ZMYND8 — LSCC

Explore this scatter interactively →