SIX2

Across TCGA patient cohorts, SIX2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIX2-associated genes across cancer lineages are Notch1, ASNS, and INPP4B. Each is linked with SIX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIX2-to-partner and partner-to-SIX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SIX2-low versus SIX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX2→partner) and Y-score (partner→SIX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.172	+3.331	.004	.005	3	2
UCEC	ASNS →	+0.645	+1.700	<.001	.044	3	2
UCEC	INPP4B →	-0.312	-3.169	.023	.018	3	1
UCEC	MEK1 →	+0.400	+3.459	.009	.005	3	1
UCEC	mTOR_pS2448 →	-0.143	-3.308	.024	.009	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.387	-3.169	.042	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Notch1 by SIX2 expression — UCEC

Explore this box plot interactively →