SIX2

Across TCGA cell cohorts, SIX2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIX2-associated genes across cancer lineages are DEFA4, TBC1D21, and OR52H1. Each is linked with SIX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIX2-to-partner and partner-to-SIX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by SIX2-low versus SIX2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX2→partner) and Y-score (partner→SIX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR52H1 →	+0.020	+3.347	.003	.005	3	1
CNS	GNG8 →	+1.555	+4.643	<.001	.003	3	1
LUNG_NSCLC_LUAD	SLC17A2 →	+0.016	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	DAZ4 →	+0.086	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

DEFA4 by SIX2 expression — LARGE_INTESTINE

Explore this box plot interactively →