Across TCGA pan-cancer cohorts, SIVA1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SIVA1 data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SIVA1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SIVA1 expression acts as an unfavorable survival marker.

BLCA, ESCA, and LGG are the cancer types where SIVA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	IV	0.051	0.600	<.001	12	view →
ESCA	DFS	Median	All	0.075	0.533	<.001	12	view →
LGG	OS	Median	All	0.307	0.811	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SIVA1 tumor-vs-normal RNA expression · all SIVA1 data types