SIT1

Across TCGA patient cohorts, SIT1 protein abundance is significantly associated with the RNA expression of many other genes, with 8,627 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIT1-associated genes across cancer lineages are CHRDL1, CD5, and NONO. Each is linked with SIT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIT1-to-partner and partner-to-SIT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIT1 versus CHRDL1 in PDAC, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIT1→partner) and Y-score (partner→SIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CHRDL1 →	+1.417	+0.420	<.001	.004	3	3
PDAC	CD5 →	+0.740	+0.390	.001	.008	3	3
LSCC	NONO →	-0.459	-0.304	<.001	<.001	3	3
PDAC	FCMR →	+1.615	+0.560	.003	.002	3	3
LSCC	UTP15 →	-0.604	-0.425	<.001	<.001	3	3
LUAD	P2RY8 →	+0.947	+0.495	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,627 associations by consensus.

SIT1 vs CHRDL1 — PDAC

Explore this scatter interactively →