SIT1

Across TCGA cell cohorts, SIT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,609 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIT1-associated GO terms across cancer lineages are Positive regulation of mRNA catabolic process, Positive regulation of mRNA metabolic process, and Viral transcription. Each is linked with SIT1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SIT1-to-partner and partner-to-SIT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mRNA catabolic process grouped by SIT1-low versus SIT1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIT1→partner) and Y-score (partner→SIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of mRNA catabolic process →	+0.041	+0.065	<.001	.008	3	7
PANCREAS	Positive regulation of mRNA metabolic process →	+0.054	+0.097	<.001	.006	3	6
LUNG_SCLC	Viral transcription →	+0.106	+0.691	<.001	.004	3	6
BLOOD_Leukemia	Regulation of microtubule-based process →	+0.037	+1.951	.003	.008	3	6
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.122	+0.186	<.001	.003	3	6
OESOPHAGUS	Response to transition metal nanoparticle →	-0.238	-0.179	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,609 associations by consensus.

Positive regulation of mRNA catabolic process by SIT1 expression — PANCREAS

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