Across TCGA patient cohorts, SIRT7 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,354 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIRT7-associated proteins across cancer lineages are NPLOC4, PCYT2, and CEP131. Each is linked with SIRT7 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIRT7-to-partner and partner-to-SIRT7 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT7→partner) and Y-score (partner→SIRT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NPLOC4 →	+0.199	+0.428	<.001	<.001	3	5
LSCC	PCYT2 →	+0.315	+0.504	<.001	<.001	3	5
BRCA	CEP131 →	+0.471	+0.511	<.001	<.001	3	5
UCEC	JPT1 →	+0.529	+0.739	<.001	<.001	3	5
OV	UFD1 →	+0.252	+0.741	<.001	<.001	3	4
GBM	IQSEC1 →	-0.423	-0.183	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,354 associations by consensus.

Exploration

SIRT7 survival (RNA) · tumor vs normal (RNA) · all SIRT7 data types