Across TCGA patient cohorts, SIRT7 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRT7-associated genes across cancer lineages are ERK2, IGFBP2, and JNK_pT183_Y185. Each is linked with SIRT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT7-to-partner and partner-to-SIRT7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT7→partner) and Y-score (partner→SIRT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.164	+2.584	.044	.010	3	1
UCEC	IGFBP2 →	-0.625	-2.222	.023	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.160	-2.321	.024	.034	3	1
UCEC	p62 Lck ligand →	+0.290	+2.222	.036	.011	3	1
UCEC	ATM →	-0.472	-2.222	.014	.011	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

SIRT7 survival (RNA) · tumor vs normal (RNA) · all SIRT7 data types